EP2 receptor agonists

A compound of formula (1)

• wherein
• A is O—CH2—, —CH═CH—or —CH2—CH2—,
• X is hydrogen or C1-C4-alkyl,
• R1 is unsubstituted phenyl, phenyl substituted by R2 or phenyl substituted by R2 and
• R3, wherein
• R2 is —(CH2)n—OH, —(CH2)qNH2, halogen, —CH2—NH(CO)R21 , —O—(CO)—N(R22)(R23)
• or
• wherein
• n is an integer from 0 to 4,
• q is an integer from 1 to 4,
• R21 is C1-C4-alkyl,
• R22 is hydrogen or C1-C2-alkyl,
• R23 is hydrogen or C1-C2-alkyl,
• R24 is NR25, CH2, O or S
• wherein
• R25 is hydrogen or C1-C2-alkyl,
• R3 is —(CH2)p—OH,
• wherein
• p is an integer from 0 to 2, and
• R4 is hydrogen or halogen,
• or a salt, a solvate, or a solvate of the salt, of formula (1).