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AssigneeLaboratorios Lesvi, S.L.
InventorsJordi Benet-Buchholz, Jordi Cerón Bertran, Glòria Freixas Pascual, Pere Dalmases Barjoan, Isabel Navarro Muñoz
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New polymorphic form of a long-acting beta-2 adrenoceptor agonist A new polymorphic form of arformoterol tartrate, designated as form D, is provided and which is characterized by at least one of the following: (i) a powder X-ray diffraction pattern having peaks at approximately 6.8, 13.3, 13.6, 3.8, 14.1, 18.2, 18.7, 20.0±0.2 degrees two theta; or (ii) a DSC thermogram showing an endothermic peak with an onset at approximately 19-120° C., and a maximum at approximately 129-131° C., followed by an exothermic peak with a maximum at approximately 137-138° C.; wherein the DSC thermogram of form D has a further endothermic peak with an onset at approximately 168-170° C.1 Processes for preparing the new polymorphic form, uses thereof and intermediates for the preparation thereof, are also provided.
A polymorphic form of arformoterol tartrate, designated as form D, which is characterized by at least one of the following:
A mixture of form D and polymorph A of arformoterol tartrate, having at least 30% (w/w) of form D.
A process for preparing arformoterol tartrate form D from arformoterol base, the process comprising the steps of:
Dependencies are inferred from the claim text.