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US 9,308,582 B2Granted
Solution stable and chemically reactive metallic nanoparticles
OwnerYi Sun, Zhuo Suninventors
Life of this patent
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Abstract
Entity and methods for generating stable and chemically reactive metallic nanoparticles and stable metallic nano-probes. Polymeric coating molecules having at least one metal core binding motif and at least one chemically reactive functional moiety is stably bound to the surface of metallic nanoparticle via the metal core binding motif. A target specific probe molecule is covalently bound to the metallic nanoparticle via the chemically reactive functional moiety forming stable metallic nano-probe.
Claims22
A method for generating polymer coated and chemically active metal nanoparticle, comprising the actions of:
- obtaining a plurality of coating polymer molecules that each of said coating polymer molecules has at least one metal core binding motif and at least one chemically reactive functional motif, wherein the chemically reactive functional motif is capable of forming covalent bonds with a specific probe molecule;
- obtaining a sufficiently sized metal nanoparticle having a metal surface;
- reacting said plurality of coating polymer molecules with said metal nanoparticle under conditions that the metal core binding motif binds to the metal surface of the metal nanoparticle to generate a chemically reactive metal nanoparticle bound with the plurality of PEG coating polymer molecules;
- purifying the chemically reactive metal nanoparticle bound with the plurality of coating polymer molecules;
- and
- reacting said chemically reactive metal nanoparticle with a cross-linker agent so that said plurality of coating polymer molecules covalently cross-linked with each other through said cross-linker agent, forming a chemically reactive polymer coated nanoparticle with a coating layer covering said metal surface of said metal nanoparticle.
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A metallic nanostructure, comprising:
- a metallic core having a metal surface;
- a plurality of coating polymer molecules that bind to the metal surface via at least one metal core binding motif;
- at least one other chemically reactive functional moiety covalently attached to each of said coating polymer molecules;
- and
- a plurality of cross-linker molecules;
- wherein said plurality of coating polymer molecules are covalently cross-linked with each other through said plurality of cross-linker molecules, forming a coating layer covering said metal surface.
3 more elements
Dependencies are inferred from the claim text.