Synthetic serous membranes and methods for making the same
AssigneeEmpire Technology Development LLC
InventorRobert Cabrera
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Abstract
The present disclosure relates to casting-mold imprints and synthetic reproductions of serous membranes for tissue engineering and organogenesis. The imprints and synthetic membranes disclosed herein may be composed of distinct biocompatible polymers, which provide a mechanism for separation. Further disclosed herein are methods for making imprints and synthetic membranes that mimic natural scrous membranes.
Claims12
A synthetic serous membrane comprising one or more biocompatible polymers that form a topological duplicate at the nano- or micro-scale level, of a donor serous membrane, wherein the topological duplicate is a synthetic pericardial, pleural, or peritoneal membrane, or any combination thereof, wherein the synthetic pericardial, pleural, or peritoneal membrane includes a two-layer membrane, wherein the synthetic serous membrane is free from the donor serous membrane and is formed without collagen.
A method for producing a synthetic serous membrane comprising:
- adding one or more biocompatible polymers to a topological imprint of a donor serous membrane, wherein the imprint is a synthetic pericardial, pleural, or peritoneal membrane imprint, or any combination thereof, and wherein the synthetic pericardial, pleural, or peritoneal imprint includes a two-layer imprint, to form a synthetic serous membrane comprising one or more biocompatible polymers that form a topological duplicate of the donor serous membrane at the nano- or micro-scale level, wherein the topological duplicate is a synthetic pericardial, pleural, or peritoneal membrane, or any combination thereof, wherein the synthetic pericardial, pleural, or peritoneal membrane includes a two-layer membrane;
- and
- removing the synthetic serous membrane from the imprint, wherein the synthetic serous membrane is free from the donor serous membrane and is formed without collagen,
- thereby producing the synthetic serous membrane comprising a topological duplicate of the donor serous membrane.
Dependencies are inferred from the claim text.