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US 9,308,284 B2Granted
Formulations of fluorinated stilbene suitable for PET imaging
AssigneePiramal Imaging SA
InventorsCarsten Olbrich, Michael Krause, Andreas Burkhard, Annett Richter, Rainer Braun
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Abstract
The invention is directed to formulations of lipophilic Amyloid beta ligand stilbene and more particularly to formulations which are capable to be administered parenterally e.g. intravenously, wherein the lipophilic Amyloid beta ligand stilbene is a fluorinated stilbene. Further, the invention is directed to a method for sterile filtration of formulations suitable for PET imaging of mammals pursuant to the invention.
Claims4
A pharmaceutical formulation comprising:
- 0.03 GBq/mL to 5 GBq/mL of Compound 2 of the following formula having an 18F fluoro radioisotope group:
- 8% v/v to 25% v/v of ethanol,
- 10% w/v to 25% w/v of poly(ethylene glycol),
- 0.01% to 3% w/v of ascorbic acid, and
- 0.01% to 20% w/v of sodium ascorbate.
2 more elements
A pharmaceutical formulation comprising:
- 0.01 μg/mL to 5 μg/mL of Compound 2 of the following formula having an 18F fluoro radioisotope group:
- 8% v/v to 25% v/v of ethanol,
- 10% w/v to 25% w/v of poly(ethylene glycol),
- 0.01% to 3% w/v of ascorbic acid, and
- 0.01% to 20% w/v of sodium ascorbate.
2 more elements
Dependencies are inferred from the claim text.