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US 9,308,268 B2Granted
Solubilized benzoyl peroxyde acne
AssigneeTransdermal Corp
InventorPankaj Modi
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Abstract
The invention relates to a novel solubilized benzoyl peroxide topical formulation for the treatment of acne comprising: benzoyl peroxide, one or more micelle forming compounds, one or more skin penetration enhancers, a surfactant, and one or more solvents, wherein the benzoyl peroxide is solubilized in the solvent. The invention further relates to the use of the topical formulation as well as the process for making the topical formulation.
Claims34
A low temperature formed solubilized benzoyl peroxide topical formulation comprising:
- benzoyl peroxide in a concentration of between 1-10% by weight and not subjected to heating;
- one or more micelle forming compounds;
- one or more solvents maintained at 25 to 40 degrees C. selected from a group of pharmaceutically acceptable, organic solvents with a low dielectric constant, wherein said benzoyl peroxide is substantially dissolved in the organic solvent with a low dielectric constant;
- one or more skin penetration enhancers maintained at 25 to 40 degrees C.;
- a surfactant maintained at 25 to 40 degrees C.;
- and
- wherein said formulation is not subjected to any heating during processing and said formulation is stable at room temperature for a period in excess of four (4) weeks.
4 more elements
A process for the preparation of a solubilized benzoyl peroxide topical formulation, said process comprising:
- a. Combining one or more micelle forming compounds, one or more penetration enhancers, one or more solvents and surfactant at 25 to 40° C. with constant stirring;
- b. Adding small molecule agent powder to the foregoing solution;
- and
- c. Cooling the resultant solution to room temperature.
1 more element
Dependencies are inferred from the claim text.