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US 9,308,265 B2Granted
Nanoparticles of cerium and amino acids
AssigneeCerion, LLC
InventorsWendi Ann Costanzo, Kenneth Joseph Reed, Bradford Michael Stadler
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Abstract
A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, an α-amino acid, an oxidant and water is provided along with temperature conditions to effectively form nanoparticles. These biocompatible nanoparticles may be further conjugated to biologically active agents, such as plasmid DNA, siRNA or proteins, such that a cell transfection agent is formed.
Claims18
A process of making nanoparticles, comprising:
- forming a reaction mixture comprising a solution of cerous ion, an α-amino acid, an oxidant, and water, wherein the α-amino acid is a compound of formula H2NCHRCOOH, wherein R is a side chain;
- adjusting said reaction mixture to a pH less than about 3;
- and
- heating or cooling said reaction mixture to a temperature in the range of about 0° C. to about 100° C. to form the nanoparticles and to directly form a dispersion of nanoparticles from the reaction mixture,
- wherein said nanoparticles have a hydrodynamic diameter of less than 100 nm.
2 more elements
Dependencies are inferred from the claim text.