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US 9,308,263 B2Granted
Pharmaceutical compositions and uses thereof
AssigneeSeachaid Pharmaceuticals, Inc.
InventorsBalasingam Radhakrishnan, Anuradha Vaidya, Navdeep Balkrishna Malkar, Karen Polowy, Kenneth Duke James, Jr.
Life of this patent
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Abstract
The invention features pharmaceutical compositions including (i) a drug, and (ii) a PEG fatty acid ester or PPG fatty acid ester in an amount sufficient to increase the oral bioavailability of the drug.
Claims43
A pharmaceutical composition in oral dosage form comprising:
- a) a drug;
- and
- b) an additive comprising from 10% to 80% (w/w) of a PEG fatty acid diester and from 0.5% to 20% (w/w) of a saccharide,
- wherein the ratio by weight of said PEG fatty acid diester to said drug is greater than 1:1 and said additive is present in an amount sufficient to increase the oral bioavailability of said drug.
1 more element
A reconstitutable pharmaceutical composition comprising from 0.5% to 20% (w/w) of a drug;
- and from 40% to 80% (w/w) of an additive comprising from 10% to 80% (w/w) of a PEG fatty acid diester and from 0.5% to 20% (w/w) of a saccharide,
- wherein the ratio by weight of said PEG fatty acid diester to said drug is greater than 1:1 and said additive is present in an amount sufficient to increase the oral bioavailability of said drug.
A kit comprising:
- a) a first container comprising a drug;
- b) a second container comprising an additive comprising from 10% to 80% (w/w) of a PEG fatty acid diester and from 0.5% to 20% (w/w) of a saccharide;
- and
- c) instructions for mixing the contents of said first container with the contents of said second container.
1 more element
A composition comprising from 10% to 80% (w/w) of a PEG fatty acid diester and from 5% to 40% (w/w) of a saccharide.
Dependencies are inferred from the claim text.