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US 9,308,262 B2Granted
Pharmaceutical composition for administration to nails
AssigneeNovaliq GmbH
InventorsBernhard Gunther, Bastian Theisinger, Sonja Theisinger
Life of this patent
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Abstract
The invention provides semi-solid or liquid pharmaceutical compositions for topical administration to a finger- or toenail of a human. The compositions are useful for the delivery of active ingredients deep into the nail. Various active ingredients may be incorporated, such as antifungal agents, anti-infectives, anti-inflammatory agents, immunosuppressants, local anesthetics, and retinoids.
Claims13
A method for the treatment of a disease or condition affecting a nail, comprising administering to the nail a topical pharmaceutical composition comprising
- an effective amount of an active ingredient which is (i) an immunosuppressant selected from the group consisting of tacrolimus, sirolimus, everolimus, pimecrolimus, ridaforolimus, temsirolimus, zotarolimus, and ciclosporin A, or (ii) an antifungal agent selected from the group consisting of clotrimazole, ketoconazole, miconazole, terbinafine, naftifine, butenafine, ciclopiroxolamine and amorolfine, and
- a semifluorinated alkane according to formula
- RFRH
- or
- RFRHRF
- wherein:
- RF is a perfluorinated hydrocarbon segment with 20 or less carbon atoms, and RH is a non-fluorinated hydrocarbon segment with 3 to 20 carbon atoms.
4 more elements
Dependencies are inferred from the claim text.