Vaccines for Chlamydia
AssigneeUniversiteit Gent
InventorDaisy Vanrompay
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Abstract
The present invention relates to means and methods to protect against disease caused by bacteria belonging to the genus Chlamydia. In particular, the present invention relates to isolated B- and T-cell epitopes derived from the major outer membrane protein of Chlamydia psittaci which can be used against an infection with a species of the genus Chlamydia. More in particular, the invention provides a vaccine which can be used against chlamydiosis caused by Chlamydia psittaci in birds and man. In addition, the invention relates to a diagnostic method to diagnose the latter infections.
Claims22
A method for eliciting an immune response in a subject against an infection of a species of the genus Chlamydia comprising administering a composition comprising one or more peptides, each of said peptides comprising one or more epitopes selected from the group consisting of a B-cell epitope, a CD4+ Th2 cell epitope, a CD4+ Th1 cell epitope and a CTL epitope;
- wherein said composition comprises at least a B-cell epitope, a CD4+ Th2 cell epitope, a CD4+ Th1 cell epitope and a CTL epitope, wherein the epitopes are located in the major outer membrane protein (MOMP) of Chlamydia psittaci, wherein the composition does not comprise the full-length Chlamydia MOMP protein, and wherein at least one of the epitopes is located in the CS1-VS1-CS2-VS2-CS3 domain of the MOMP.
A method of treating, reducing the symptoms and/or clinical signs of, or reducing the risk for an infection of a species of the genus Chlamydia comprising administering a composition comprising one or more peptides, each of said peptides comprising one or more epitopes selected from the group consisting of a B-cell epitope, a CD4+Th2 cell epitope, a CD4+ Th1 cell epitope and a CTL epitope;
- wherein said composition comprises at least a B-cell epitope, a CD4+ Th2 cell epitope, a CD4+ Th1 cell epitope and a CTL epitope, wherein the epitopes are located in the major outer membrane protein (MOMP) of Chlamydia psittaci, wherein the composition does not comprise the full-length Chlamydia MOMP protein, and wherein at least one of the epitopes is located in the CS1-VS1-CS2-VS2-CS3 domain of the MOMP.
Dependencies are inferred from the claim text.