Spray dried compositions and methods of use
AssigneeLife-Science Innovations, LLC
InventorsBobby Gene Poe, III, Jared Randall Huisinga
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Abstract
Provided herein are insoluble particles that include polypeptides. The polypeptides may have immunogenicity that is greater than the immunogenicity of the same polypeptides when they are not present in the particle. The polypeptides may be soluble before incorporation into the particles and insoluble after incorporation into the particles. The particles may include lipopolysaccharide, wherein the lipopolysaccharide is insoluble. The particles may include a carrier. In one embodiment, a carrier is present at no greater than 0.001 mg carrier/mg particles. In one embodiment, a carrier is present at a ratio of carrier to polypeptide (weight:weight) of no greater than 0.05:1. In one embodiment, a carrier is not detectable in the particles.
Claims25
A method for decreasing exposure of an animal to lipopolysaccharide comprising administering to an animal a composition comprising spray dried insoluble dry powder, wherein the spray dried insoluble dry powder comprise polypeptides obtained from a gram negative microbe and lipopolysaccharide, wherein solubility of the lipopolysaccharide in aqueous solution is reduced compared to solubility of lipopolysaccharide not present in the spray dried insoluble dry powder, wherein the powder comprises particles, and wherein the polypeptides are present at a concentration of at least 0.1 mg polypeptide/mg particles.
Dependencies are inferred from the claim text.