Methods and compositions for treatment of retinoid-responsive conditions
AssigneeThe Penn State Research Foundation
InventorsDiane Thiboutot, Amanda Nelson, Kimberly Lumsden
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Abstract
Methods and composition for treating a retinoid-responsive condition in a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a substance selected from the group consisting of: neutrophil gelatinase-associated lipocalin (NGAL), an NGAL analog, an NGAL stimulator and an analog of an NGAL stimulator, to a subject having a retinoid-responsive condition. Retinoid-responsive conditions illustratively include acne, rosacea, psoriasis, promyelocytic leukemia and neuroblastoma.
Claims5
A method of treating acne in a subject, comprising:
- administering a therapeutically effective amount of an NGAL stimulator, wherein the NGAL stimulator is selected from the group consisting of:
- a Toll-like receptor 2 ligand, a Toll-like receptor 3 ligand, an activator of NFκB, leukotriene B4, cholesterol oleate and interleukin-17 (IL-17), to a subject having acne.
Dependencies are inferred from the claim text.