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US 9,308,237 B2Granted
Papillomavirus virus-like particle or capsomere formulation and its use as microbicide
AssigneeUniversity of Rochester
InventorWilliam Bonnez
Life of this patent
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Abstract
Methods and compositions for preventing viral infection are disclosed. Compositions containing papillomavirus VLPs or capsomeres are used, alone or in combination with other agents, as microbicides that substantially block papillomavirus binding receptors on the surface or vicinity of cells in a tissue to be treated with the composition. The invention can be used to inhibit papillomavirus infection or infection by another virus that utilizes the same binding receptors during the infection process.
Claims15
A method of temporarily inhibiting virus infection incidental to sexual activity of an individual, the method comprising:
- providing a microbicide composition comprising a plurality of non-infectious papillomavirus virus-like particles or capsomeres;
- and
- contacting, via topical administration, mucosa or skin tissue of an individual with the composition to block papillomavirus binding receptors on the surface or vicinity of cells in the contacted mucosa or skin,
- wherein said contacting is carried out prior to each sexual activity that poses a threat of exposure of the contacted mucosa or skin to a virus, and said contacting is effective temporarily to inhibit virus infection or virus-induced tissue proliferation of contacted mucosa or skin.
1 more element
Dependencies are inferred from the claim text.