Methods and compositions for treating mucosal tissue disorders
AssigneeThe University of North Carolina at Chapel Hill
InventorsRoland R. Arnold, David C. Henke
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Abstract
The present invention provides compositions and formulations comprising glutathione with or without thiocyanate and methods of use thereof to treat diseases and disorders in mucosal/epithelial tissue.
Claims26
A method for treating a pulmonary or airway disorder or disease by inhibiting microbial growth in an airway of a subject in need thereof, comprising administering to the airway of the subject an effective amount of a composition comprising:
- a) a glutathione, or a pharmaceutically-acceptable salt of glutathione;
- b) an organic acid or a pharmaceutically-acceptable salt of an organic acid;
- and
- c) a bicarbonate salt,
- wherein the pulmonary or airway disorder or disease is selected from the group consisting of chronic inflammatory lung disease, inflammation and/or infection associated with lung transplantation, acute lung rejection, asthma, cystic fibrosis, chronic obstructive pulmonary disease (COPD) and any combination thereof, thereby treating the pulmonary or airway disorder or disease by inhibiting microbial growth in the airway of the subject.
A method of restoring homeostasis to and/or maintaining homeostasis in a mucosal membrane of a subject with a pulmonary or airway disorder or disease by inhibiting microbial growth in an airway of the subject, comprising administering to the airway of the subject an effective amount of a composition comprising:
- a) a glutathione, or a pharmaceutically-acceptable salt of glutathione;
- b) an organic acid, or a pharmaceutically-acceptable salt of an organic acid;
- and
- c) a bicarbonate salt,
- wherein the pulmonary or airway disorder or disease is selected from the group consisting of chronic inflammatory lung disease, inflammation and/or infection associated with lung transplantation, acute lung rejection, asthma, cystic fibrosis, chronic obstructive pulmonary disease (COPD) and any combination thereof, thereby restoring homeostasis to and/or maintaining homeostasis in the mucosal membrane of the subject by inhibiting microbial growth in the airway of the subject.
A method of inhibiting microbial growth in an airway of a subject, comprising administering to the airway of the subject an effective amount of a composition comprising:
- a) a glutathione, or a pharmaceutically-acceptable salt of glutathione;
- b) an organic acid, or a pharmaceutically-acceptable salt of an organic acid;
- and
- c) a bicarbonate salt,
- thereby inhibiting microbial growth in the airway of the subject.
Dependencies are inferred from the claim text.