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US 9,308,227 B2Granted
Lactic acid bacteria and compositions containing them against bacterial colds
AssigneeOrganobalance Medical AG
InventorsChristine Lang, Andreas Raab, Natalia Bolotina
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Abstract
The invention describes a microorganism of the order of lactic acid bacteria or an analog, fragment, derivative, mutant or combination thereof, wherein the microorganism, or analog, fragment, derivative, mutant or combination thereof can coaggregate with Streptococcus pyogenes.
Claims28
A method for identifying and/or selecting a lactic acid bacterium that coaggregates with Streptococcus pyogenes, wherein the method comprises:
- incubating Streptococcus pyogenes under conditions under which Streptococcus pyogenes forms a biofilm,
- adding the lactic acid bacterium to be investigated to a mixture for coaggregation between the Streptococcus pyogenes and the lactic acid bacterium and incubation of the mixture, and
- separating any unbound lactic acid bacteria by removing a supernatant and determining a presence of coaggregated lactic acid bacteria in the biofilm formed by Streptococcus pyogenes.
A method for coaggregation comprising:
- administering to a patient in need of treatment, prophylaxis and/or therapy of microbial diseases or inflammatory diseases of the skin, mucous membranes or oral cavity a microorganism belonging to the lactic acid bacterium order, wherein the microorganism is Lactobacillus lactis, Lactobacillus helveticus, Lactobacillus jensenii, Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus amylovorus, Lactobacillus delbrueckii, Lactobacillus casei, Lactobacillus crispatus, Lactobacillus gassed, Lactobacillus johnsonii, Lactobacillus paracasei, Lactobacillus pentosus, Lactobacillus rhamnosus, Lactobacillus curvatus, Lactobacillus plantarum, Lactobacillus brevis, Lactobacillus buchneri, Lactobacillus fructivorans, Lactobacillus hilgardii, Lactobacillus fermentum, Lactobacillus reuteri, Lactobacillus viridescens, Bifidobacterium bifidum or Lactobacillus ingluviei, wherein the lactic acid bacterium administered aggregates at least with Streptococcus pyogenes.
Dependencies are inferred from the claim text.