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US 9,308,225 B2Granted
Compositions and methods for preventing cardiac arrhythmia
AssigneeCorMatrix Cardiovascular, Inc.
InventorRobert G Matheny
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compositions and methods for treating or preventing cardiac arrhythmia in a subject.
Claims2
A method of treating post-operative atrial fibrillation in a subject, comprising:
- providing an extracellular matrix (ECM) composition comprising acellular ECM from a mammalian tissue source, said tissue source comprising small intestine submucosa, wherein, when said ECM composition is administered to damaged myocardium tissue of said subject, said ECM composition induces myofibroblast proliferation and angiogenesis and, thereby, bioremodeling and regeneration of new myocardium tissue;
- and
- delivering a therapeutically effective amount of said ECM composition directly to post-operative damaged myocardium tissue of said subject, wherein said ECM composition, wherein said ECM composition modulates electrical activity in the heart of said subject, whereby said ECM composition reduces incidence of post-operative atrial fibrillation of said subject.
A method of treating post-operative atrial fibrillation in a subject, comprising:
- providing an extracellular matrix (ECM) composition comprising acellular ECM from a mammalian tissue source, said tissue source comprising amniotic membrane, wherein, when said ECM composition is administered to damaged myocardium tissue of said subject, said ECM composition induces myofibroblast proliferation and angiogenesis and, thereby, bioremodeling and regeneration of new myocardium tissue;
- and
- delivering a therapeutically effective amount of said ECM composition directly to post-operative damaged myocardium tissue of said subject, wherein said ECM composition, wherein said ECM composition modulates electrical activity in the heart of said subject, whereby said ECM composition reduces incidence of post-operative atrial fibrillation of said subject.
Dependencies are inferred from the claim text.