Pharmaceutical compositions for the oral administration of heparin or derivatives thereof
AssigneeCosmo Technologies Limited
InventorsMauro Ajani, Luigi Moro, Roberto Villa
Life of this patent
Estimating the term…
Abstract
Oral pharmaceutical compositions for the controlled release of heparin or derivatives thereof, for example dalteparin, salts and/or derivatives thereof, comprising (a) a matrix consisting of amphiphilic compounds and lipophilic compounds with melting point lower than 90° C. in which the active ingredient is at least partially dispersed; (b) an outer hydrophilic matrix in which the lipophilic/amphiphilic matrix is dispersed; (c) optionally, other excipients suitable for solid pharmaceutical forms. The treatment of inflammatory bowel diseases (IBD) by administering to a patient in need thereof an effective amount of dalteparin, salts and/or derivatives thereof is also disclosed.
Claims13
An oral pharmaceutical composition for the controlled release of dalteparin, salts and/or derivatives thereof, comprising:
- a) a lipophilic/amphiphilic matrix which comprises at least one amphiphilic compound and at least one lipophilic compound with a melting point below 90° C. in which at least dalteparin, salts and/or derivatives thereof is at least partially dispersed;
- b) a hydrophilic matrix which comprises at least one hydrophilic compound in which the lipophilic/amphiphilic matrix is dispersed;
- and
- c) other physiologically acceptable excipients, said amphiphilic compounds being selected from the group consisting of polar lipids type I or II, glycol alkyl ethers, polyoxyethylenated castor oil, polysorbate, phosphoacetylcholine, sodium laurylsulfate, fatty acid sucroesters and polyethylene glycols,
- wherein the dalteparin, salts and/or derivatives thereof is dispersed both in the hydrophilic matrix and in the lipophilic/amphiphilic matrix;
- wherein the oral composition is in the form of tablets, capsules or mini-matrices;
- and
- wherein the dosage range of dalteparin, salts and/or derivatives thereof is 5-1000 mg per single dose.
Dependencies are inferred from the claim text.