Flat self-curling permeable sheet membrane
AssigneeCollagen Matrix, Inc.
InventorsShu-Tung Li, Natsuyo Shishido Lee, Debbie Yuen
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Abstract
A flat self-curling permeable sheet membrane containing a matrix formed of crosslinked biopolymeric fibers. The matrix self-curls into a predetermined shape upon absorption of an aqueous fluid and is permeable to molecules having molecular weights not greater than 1×106 daltons. Also disclosed is a method of preparing such a flat self-curling permeable membrane.
Claims20
A dry flat self-curling permeable sheet membrane comprising a flat layer of crosslinked collagen fibers, wherein the sheet membrane is free of chitosan and glycosaminoglycan, and the flat layer self-curls into a predetermined shape upon absorption of an aqueous fluid, the predetermined shape being a v, a tube, an arch, or a channel, and is permeable to molecules having molecular weights not greater than 1×106 daltons.
A method for preparing a dry flat self-curling permeable sheet membrane, the method comprising:
- reconstituting biopolymeric fibers dispersed in a solution;
- forming a permeable sheet membrane containing a layer of the reconstituted biopolymeric fibers;
- folding the sheet membrane in a hydrated state into a predetermined shape;
- crosslinking the biopolymeric fibers while the folded sheet membrane is kept in the predetermined shape;
- and
- flattening the folded sheet membrane in a hydrated state followed by drying, thereby forming a flat membrane that self-curls into the predetermined shape upon absorption of an aqueous fluid,
- wherein the predetermined shape is a v, a tube, an arch, or a channel, the sheet membrane is free of chitosan and glycosaminoglycan, and the biopolymeric fibers are collagen fibers.
A dry flat self-curling permeable sheet membrane prepared by the steps of:
- reconstituting biopolymeric fibers dispersed in a solution;
- forming a permeable sheet membrane containing a layer of the reconstituted biopolymeric fibers;
- folding the sheet membrane in a hydrated state into a predetermined shape;
- crosslinking the biopolymeric fibers while the folded sheet membrane is kept in the predetermined shape;
- and
- flattening the folded sheet membrane in a hydrated state followed by drying, thereby forming a flat membrane that self-curls into the predetermined shape upon absorption of an aqueous fluid,
- wherein the predetermined shape is a v, a tube, an arch, or a channel, the sheet membrane is free of chitosan and glycosaminoglycan, and the biopolymeric fibers are collagen fibers.
A dry flat self-curling permeable sheet membrane consisting of a flat layer of crosslinked collagen fibers, wherein the flat layer self-curls into a predetermined shape upon absorption of an aqueous fluid, the predetermined shape being a v, a tube, an arch, or a channel, and is permeable to molecules having molecular weights not greater than 1×106 daltons.
Dependencies are inferred from the claim text.