Aerosol generating method and device
AssigneeAlexza Pharmaceuticals, Inc.
InventorsMartin J. Wensley, Daniel Mufson, Craig C. Hodges, Peter M. Lloyd, Daniel D. Rogers
Life of this patent
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Abstract
A method and device are provided to generate an aerosol having a desired particle sizes, i.e., from molecular to about 10 microns, which can be used to effectively deliver a physiologically active compound to organs and tissues such as the lung, eye, mucosa and skin. The aerosol is formed through vaporization of the compound while mixing the resulting vapor with a gas, in a ratio, to form the desired particle size when a stable concentration of particles in the gas is reached.
Claims32
A method for generating an aerosol comprising the steps of:
- (a) depositing a coating comprising a physiologically active compound onto a substrate comprising dissolving the compound in an organic solvent, applying the solution to all or a portion of the substrate and allowing the solvent to evaporate;
- (b) heating the physiologically active compound to vaporize at least a portion of the compound, following said evaporation;
- (c) cooling the resulting vapor by mixing the vapor with a gas in a predetermined ratio, selected to form an aerosol comprised of particles within a desired size range when a stable concentration of particles in the gas is reached.
A method for generating an aerosol comprising the steps of:
- (a) depositing a coating comprising a physiologically active compound onto a substrate comprising dissolving the compound in an organic solvent, applying the solution to all or a portion of the substrate and allowing the solvent to evaporate;
- (b) heating a coating comprising a therapeutic amount of said physiologically active compound deposited onto said substrate to vaporize at least a portion of the compound, following said evaporation;
- (c) cooling the resulting vapor by mixing the vapor with a gas in a predetermined ratio, selected to form an aerosol comprised of particles within a desired size range when a stable concentration of particles in the gas is reached.
A method for generating an aerosol comprising the steps of:
- (a) depositing a coating comprising a physiologically active compound onto a substrate comprising dissolving the compound in an organic solvent, applying the solution to all or a portion of the substrate and allowing the solvent to evaporate
- (b) heating the physiologically active compound to vaporize at least a portion of the compound, following said evaporation;
- (c) cooling the resulting vapor by mixing the vapor with a gas in a predetermined ratio, selected to form an aerosol comprised of particles within a desired size range that are sufficiently stable that they will remain within that range during the time necessary to administer the aerosol to a patient.
A method for generating an aerosol comprising the steps of:
- (a) depositing a coating comprising a compound onto a substrate comprising dissolving the compound in an organic solvent, applying the solution to all or a portion of the substrate and allowing the solvent to evaporate;
- (b) heating a coating comprising a therapeutic amount of a physiologically active compound deposited onto said substrate to vaporize at least a portion of the compound, following said evaporation;
- (c) cooling the resulting vapor by mixing the vapor with a gas in a predetermined ratio, selected to form an aerosol comprised of particles within a desired size range that are sufficiently stable that they will remain within that range during the time necessary to administer the aerosol to a patient.
Dependencies are inferred from the claim text.