Pressure sensitive adhesive matrix device or system for the treatment or prevention of onychomycosis or tinea pedis

A method for the transdermal treatment of fungal toenails or fingernails or foot infections with an antifungal agent comprising adhesively securing to a dorsal side of an infected palm or foot a pressure-sensitive adhesive matrix patch device comprising:

• (a) an impermeable backing layer,
• (b) a matrix layer having a first surface and a second surface opposite the first surface, wherein the first surface is adhered to the backing layer and the second surface is adapted to be in diffusional skin contact with a dorsal side of an infected palm or foot, the matrix layer comprising:
• (i) a pressure-sensitive adhesive, wherein the pressure-sensitive adhesive is an acrylic adhesive;
• (ii) an amount of an antifungal agent sufficient to provide an antifungal effect contained in the adhesive, wherein the antifungal agent is selected from 2% to 8% by weight of terbinafine and a combination of 2% to 8% by weight of terbinafine and 1% to 5% by weight of ketoconazole, based on weight of the matrix layer;
• and
• (iii) 5% to 10% by weight of a permeation enhancer based on the weight of the matrix layer, wherein the permeation enhancer is lauryl lactate;
• and
• (c) a release liner;
• the device being adhesively secured to the dorsal side of the infected palm or foot for a time sufficient to deliver an effective amount of the antifungal agent to an area of infection.