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US 9,308,193 B2Granted
Kinase inhibitors for the treatment of cancer
AssigneePitney Pharmaceuticals Pty Limited
InventorDavid Lawson Morris
Life of this patent
Estimating the term…
Abstract
The present invention relates to kinase inhibitors for the treatment of cancer. Specifically, the present invention relates to the use of aminoactonitrile derivatives (AADs) in the treatment of cancer.
Claims20
A method for the treatment of one or more cancers, the method comprising administering a therapeutically effective amount of a compound of formula (I):
- or a pharmaceutically acceptable salt, solvate or prodrug thereof to a patient in need thereof, wherein
- i) R1 is alkyl, —CF3 or —CN and R4 is selected from H, alkyl, halogen, alkoxy, —CF3, —OCF3, —SO2—CF3, —SO—CF3 or —S—CF3;
- or ii) R4 is H, alkyl, halogen, alkoxy,—S—CF3, —SOCF3 or —SO2CF3 and R1 is selected from H, alkyl, halogen, —CF3 or —CN;
- R2 and R3 and R5 are each independently selected from H, alkyl, halogen, —CF3 or —CN;
- R6 is independently selected from H, alkyl, halogen, alkoxy, —CF3, —OCF3, —SO2CF3, —SO—CF3 or —S—CF3;
- X is heteroatom, N(alkyl) or NH;
- and
- n is 1 to 20 wherein the cancer is selected from ovarian cancer, breast cancer, colon cancer, mesothelioma, cervical cancer, prostate cancer, skin cancer, glioma, liposarcoma, fibrosarcoma and leukemia.
5 more elements
Dependencies are inferred from the claim text.