Methods and compositions to enhance bone growth comprising a statin
AssigneeWarsaw Orthopedic, Inc.
InventorsPing Li, Jeffrey C. Marx, William F. McKay
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Abstract
Implantable medical devices and methods are provided that have one or more statins disposed therein. The medical devices may be implanted at near or in a bone defect to enhance bone growth. In some embodiments, the medical device provided allows for sustain release of the statin and facilitates bone formation and repair of the fracture site.
Claims17
An implantable medical device configured to fit at, near or in a bone defect, the medical device comprising a biodegradable polymer, a therapeutically effective amount of a statin disposed throughout the medical device to facilitate bone growth, and trehalose, the polymer comprising poly(DL-lactide-co-glycolide), the medical device having an inherent viscosity of about 0.34 dL/g, the statin comprising at least cerivastatin, atorvastatin, simvastatin, pravastatin, fluvastatin, lovastatin, rosuvastatin, eptastatin, pitavastatin, velostatin, fluindostatin, dalvastain, or pharmaceutically acceptable salts thereof or a combination thereof, wherein the medical device allows influx of at least progenitor, and/or bone cells at, near or in the bone defect.
Dependencies are inferred from the claim text.