Glyco-substituted dihydroxy-chlorins and β-functionalized chlorins for anti-microbial photodynamic therapy

A carbohydrate and dihydroxychlorin conjugate compound comprising formula:

• wherein B is independently selected from the group consisting of:
• wherein each R is an independently selected substituent comprising one or more carbohydrate groups;
• and
• wherein each R2 is independently selected from the group consisting of alkyl or fluoroalkyl groups consisting of 1-15 carbon atoms, a phenyl ring, and a phenyl ring with one or more substituent X;
• wherein said substituent X of the phenyl ring is in the ortho-, meta- or para-position of the phenyl ring;
• wherein said substituent X is selected from the group consisting of OH, —COOH, —NH2, —CF3, —F, —COOY, —NHY, —OY, —NH—Z—COOH, and —CO—Z—NH2;
• wherein Y is selected from the group consisting of a polyethylene glycol residue containing a (CH2CH2O)n moiety with n=1-30 and a carbohydrate moiety;
• and
• wherein Z is selected from the group of peptides and oligopeptides.