Topical formulations, systems and methods
AssigneeNuvo Research Inc.
InventorsEdward T. Kisak, John M. Newsam, Dominic King-Smith, Pankaj Karande, Samir Mitragotri, Tejas Desai, Wade A. Hull
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Abstract
The present disclosure is drawn to topical formulations, transdermal systems, and related methods. In one embodiment, a topical formulation is provided that includes a local anesthetic, a first compound, and a second compound. The first compound and second compound are different and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate, and sodium lauryl sulfoacetate.
Claims127
A topical formulation, comprising:
- a local anesthetic,
- a first compound, and
- a second compound,
- wherein the first compound and second compound are different and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate, and sodium lauryl sulfoacetate.
A method of treating a subject with existing pain or at risk of developing pain, comprising:
- applying a system for transdermal delivery of a local anesthetic to a skin surface of the subject, said system, comprising:
- a topical formulation, including a local anesthetic, a first compound, and a second compound, wherein the first compound and second compound are different and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate, and sodium lauryl sulfoacetate;
- and optionally
- a heating component capable of heating the skin surface to a temperature of 35° C. to 47° C., and
- maintaining the system on the skin surface for a period of time of at least 15 minutes such that the topical formulation is in contact with the skin surface and the heating component is activated to apply the temperature to the topical formulation or the skin surface.
A method of improving the physical stability of a topical formulation including a local anesthetic, comprising admixing a first compound and a second compound with the local anesthetic and water, wherein the first compound and second compound are different and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate, and sodium lauryl sulfoacetate.
A system for transdermal delivery of a local anesthetic, comprising:
- a topical formulation, including a local anesthetic, a first compound, and a second compound, wherein the first compound and second compound are different and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate, and sodium lauryl sulfoacetate;
- and
- a heating component capable of heating the skin surface to a temperature of 35° C. to 47° C.
Dependencies are inferred from the claim text.