Pharmaceutical formulation containing gelling agent
AssigneesPurdue Pharma L.P., The P.F. Laboratories, Inc., Purdue Pharmaceuticals L.P.
InventorsCurtis Wright, Benjamin Oshlack, Christopher Breder
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Abstract
Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.
Claims24
An immediate release oral dosage form comprising:
- a compressed mixture, comprising:
- a therapeutically effective amount of oxycodone hydrochloride;
- a gelling agent comprising polyethylene oxide, the polyethylene oxide in a ratio to oxycodone hydrochloride from about 1:1 to about 8:1 by weight;
- a disintegrant;
- sodium lauryl sulfate;
- and
- magnesium stearate,
- the dosage form providing an immediate release of the oxycodone hydrochloride when orally administered to a human patient.
Dependencies are inferred from the claim text.