Pharmaceutical formulation containing gelling agent
AssigneesPurdue Pharma L.P., The P.F. Laboratories, Inc., Purdue Pharmaceuticals L.P.
InventorsCurtis Wright, Benjamin Oshlack, Christopher Breder
Life of this patent
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Abstract
Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.
Claims17
An immediate release oral dosage form comprising:
- a mixture of (i) a central nervous system stimulant;
- (ii) a gelling agent comprising hydroxypropylcellulose, the gelling agent in an effective amount to impart a viscosity of at least 10 cP when the dosage form is subjected to tampering by dissolution in from about 0.5 to about 10 ml of an aqueous liquid;
- and
- wherein the weight ratio of the hydroxypropylcellulose to the central nervous system stimulant is about 1:1 to about 8:1;
- (iii) microcrystalline cellulose;
- (iv) a material selected from a group consisting of polyethylene glycol, polyethylene oxide, and mixtures thereof;
- (v) silicon dioxide;
- (vi) a disintegrant;
- and
- (vii) a lubricant;
- the dosage form providing an immediate release of the central nervous system stimulant.
An immediate release oral dosage form comprising:
- a mixture of (i) a central nervous system stimulant;
- (ii) a gelling agent comprising hydroxypropylcellulose, the gelling agent in an effective amount to impart a viscosity of about 10 cP or greater when the dosage form is subjected to tampering by dissolution in about 0.5 ml to about 10 ml of an aqueous liquid;
- and
- wherein the weight ratio of the hydroxypropylcellulose to the central nervous system stimulant is about 1:1 to about 8:1;
- (iii) microcrystalline cellulose;
- (iv) polyethylene oxide with a weight average molecular weight of about 100,000 daltons to about 10,000,000 daltons;
- (v) silicon dioxide;
- (vi) a disintegrant;
- and
- (vii) a lubricant;
- the dosage form providing an immediate release of the central nervous system stimulant.
An immediate release oral dosage form comprising:
- a mixture of (i) a central nervous system stimulant;
- (ii) hydroxypropylcellulose, wherein the weight ratio of the hydroxypropylcellulose to the central nervous system stimulant is about 1:1 to about 8:1;
- (iii) microcrystalline cellulose;
- (iv) polyethylene oxide, polyethylene glycol or a mixture thereof;
- (v) silicon dioxide;
- (vi) a disintegrant;
- and
- (vii) a lubricant;
- wherein the dosage form provides an immediate release of the central nervous system stimulant.
Dependencies are inferred from the claim text.