Microspheres for active embolization
AssigneeBiosphere Medical, Inc.
InventorsJean-Marie Vogel, Egisto Boschetti
Life of this patent
Estimating the term…
Abstract
The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
Claims25
An MRI-detectable, substantially spherical microsphere suitable for active embolization, comprising:
- an iron oxide particle;
- a biocompatible, hydrophilic, non-biodegradable polymeric material, wherein the polymeric material comprises an acrylamide moiety and an ionic moiety;
- and
- an anti-neoplastic agent, wherein the anti-neoplastic agent is associated with the polymeric material by an ionic interaction with the ionic moiety.
A method for active embolization, comprising administering to a patient an MRI-detectable, substantially spherical microsphere comprising:
- an iron oxide particle;
- a biocompatible, hydrophilic, non-biodegradable polymeric material, wherein the polymeric material comprises an acrylamide moiety and an ionic moiety;
- and
- a positively-charged drug, wherein the positively-charged drug is associated with the polymeric material by an ionic interaction with the ionic moiety.
Dependencies are inferred from the claim text.