Nanoparticle isoflavone compositions and methods of making and using the same

A method of making a genistein formulation comprising:

• combining genistein with a pharmaceutically acceptable suspension medium, the pharmaceutically acceptable suspension medium comprising an aqueous carrier;
• and
• nanomilling the combined genistein and pharmaceutically acceptable suspension medium to form a genistein formulation comprising nanoparticulate genistein exhibiting a particle size distribution characterized by a D (0.50) of 0.5 μm or less,
• wherein the nanoparticulate genistein is present in the genistein formulation at a concentration of between 250 mg/mL and 500 mg/mL.