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AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsDorian B. McGavern, Theodore Roth
Estimating the term…
Disclosed is a method of treating or preventing a disease or disorder of the central nervous system (CNS) in a patient comprising administering transcranially, for example, directly to the skull, an effective amount of an anti-inflammatory agent to the patient. Examples of the anti-inflammatory agent include glutathione and inhibitors of purinergic receptors such as P2X4, P2X7, P2Y6, and P2Y12 receptors. Examples of disease or disorder of the CNS include brain injury, particularly traumatic brain injury, inflammation, infection, degeneration of brain cells, stroke, brain edema, tumor, Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Also disclosed is a kit comprising at least one anti-inflammatory agent and printed materials containing instructions for transcranially administering the anti-inflammatory agent to the patient having a disease or disorder of the CNS, disorder of the CNS.
A method of treating a disease or disorder of the central nervous system (CNS) in a patient comprising administering transcranially an effective amount of an anti-inflammatory agent to the patient, wherein the anti-inflammatory agent is administered in an aqueous vehicle, and wherein the disease or disorder of the CNS is traumatic brain injury, inflammation of the brain, or stroke, wherein the anti-inflammatory agent is glutathione or a purinergic receptor inhibitor selected from trinitrophenyl-ATP hydrate, oxidized ATP, N,N″-1,4-butanediylbis[N′-3-isothiocyanatophenyl)]thiourea, and MeSAMP, and wherein the transcranial administration comprises direct application of the anti-inflammatory agent to a skull of the patient, application of the anti-inflammatory agent to the skull through a scalp of the patient, or application of the anti-inflammatory agent into a skull bone of the patient.
Dependencies are inferred from the claim text.