Method for producing elastic vesicles
AssigneeGreenjoy Biotech Co., LTD.
InventorsJaw-Cherng Hsu, Ying-Hsuan Wu
Life of this patent
Estimating the term…
Abstract
A method for producing elastic vesicles enveloping active ingredients includes pre-emulsification of a formulation of elastic vesicles and a homogenization step. The pre-emulsification of a formulation of elastic vesicles includes heating and uniformly mixing water of a water phase of the formulation and active ingredients until the active ingredients completely dissolve in the water, and adding an oil phase of the formulation premixed with edge activators to accomplish the pre-emulsification. The homogenization step includes using a device for miniaturizing or nanometerizing particles to proceed with disruption and homogenization.
Claims13
A method for producing elastic vesicles enveloping at least one hydrophilic active ingredient comprising:
- heating and uniformly mixing water and the at least one hydrophilic active ingredient until the at least one hydrophilic active ingredient completely dissolves in the water to form a water phase;
- lowering the temperature of the water phase;
- mixing a phospholipid and an edge activator in an oil phase, the phospholipid selected from the group consisting of phosphatidylcholine (PC), phosphatidylinostiol (PI), phosphatidvethanolamine (PE), and phosphatidic acid (PA);
- adding the oil phase to the water phase to accomplish pre-emulsification of the formulation of elastic vesicles;
- and
- miniaturizing or nanometerizing particles of the formulation of elastic vesicles to proceed with disruption and homogenization of the formulation such that elastic vesicles enveloping active ingredients are formed,
- wherein the method does not use organic solvents, and
- wherein the elastic vesicles are capable of transdermal delivery of the at least one active substance.
Dependencies are inferred from the claim text.