Devices, systems, and methods for performing atherectomy including delivery of a bioactive material

A method of treating a region of a blood vessel comprising:

• identifying a first arterial site at or below the knee having occlusive material forming a lesion;
• introducing a distal end of a catheter at an access site above the knee, wherein the catheter comprises a cutting assembly at the distal end of the catheter and a slotted tube comprising a first slot pattern in a proximal portion of the catheter and a second slot pattern in a distal portion of the catheter, the cutting assembly comprising:
• a distal cutter with one or more fluted cutting edges;
• a cutting core adapter having a number of fluted cutting edges greater than that of the distal cutter;
• and
• a housing comprising a forward cutting surface, wherein the cutter is located concentrically within the housing;
• advancing the cutting assembly to the first arterial site;
• rotating the distal cutter of the cutting assembly to remove occlusive material from the lesion;
• cutting or grinding the occlusive material into smaller pieces using the cutter core adapter;
• and
• removing the occlusive material through an aspiration port.