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US 9,307,968 B2Granted
Materials and methods for filling biological cavities and preventing leakage of injected therapeutic agents
AssigneeThe University of Hong Kong
InventorsBarbara Pui Chan, Tsz Kit Chik, Tsz Hang Andrew Choy, Xuanyi Ma, K. M. C. Cheung
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Abstract
The subject invention pertains to medical apparatuses and methods for reducing or preventing leakage of injected therapeutic agents (including liquid-containing substances, cells) into a solid or hollow tissue/organ after puncturing.
Claims6
A method for preventing leakage of therapeutic agents from a target site in an annulus of an intervertebral disc through an injection opening created by an injection needle, the injection opening having a certain length, wherein the method comprises:
- delivering the therapeutic agents to the target site in a subject using an apparatus while creating the injection opening adjacent to the target site, the injection opening comprising an exterior end, wherein the apparatus comprises the injection needle comprising a plunger, and a transparent tubing connecting a first detachable portion with the injection needle;
- closing the tubing;
- removing the first detachable portion from the tubing;
- attaching a second detachable portion comprising a needle shaped plug to the tubing;
- marking the second detachable portion to indicate the length of the injection opening;
- opening the tubing;
- delivering the needle shaped plug to fill the injection opening by pushing the injection needle plunger and stopping at the marking of the second detachable portion,
- removing the apparatus;
- and
- applying a biocompatible adhesive to the exterior end of the injection opening.
7 more elements
Dependencies are inferred from the claim text.