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US 9,303,273 B2Granted
Nanolipoprotein particles comprising a natural rubber biosynthetic enzyme complex and related products, methods and systems
AssigneesLawrence Livermore National Security, LLC, The United States of America as represented by the Secretary of Agriculture
InventorsPaul D. Hoeprich, Maureen Whalen
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Abstract
Provided herein are nanolipoprotein particles that comprise a biosynthetic enzyme more particularly an enzyme capable of catalyzing rubber or other rubbers polymerization, and related assemblies, devices, methods and systems.
Claims15
A nanolipoprotein particle comprising
- a target protein,
- a membrane forming lipid, and
- a scaffold protein,
- wherein the target protein is a natural rubber transferase complex (RuT), wherein the natural rubber transferase complex is provided within a discoidal membrane lipid bilayer formed by the membrane forming lipid and stabilized by the scaffold protein, and wherein the membrane lipid bilayer is attached to the RuT through interaction of the natural rubber transferase complex hydrophobic region with the membrane lipid bilayer.
1 more element
Dependencies are inferred from the claim text.