Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof
AssigneeBoard of Trustees of the University of Arkansas
InventorsSamuel M. Owens, Frank Ivy Carroll, Philip Abraham
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Abstract
The invention generally relates to hapten compounds comprising either (+) methamphetamine or (+) amphetamine conjugated to a linker. Generally speaking, hapten compounds of the invention may be used to elicit an immune response to one or more of (+) methamphetamine, (+) amphetamine, or (+) MDMA.
Claims6
A method for generating a monoclonal antibody or an antigen binding fragment thereof, the method comprising generating the monoclonal antibody or the antigen binding fragment thereof using an immunogen comprising a hapten conjugated to an immunogenic carrier, wherein said hapten has the structure
- wherein said immunogenic carrier is conjugated to said hapten via the carboxylic group of the hapten, and
- wherein:
- R1 is selected from the group consisting of hydrogen and methyl;
- and
- L is selected from the group consisting of O(CH2)5 attached to the benzene ring at the meta position, and O(CH2)9attached to the benzene ring at the meta position, wherein indicates point of attachment to the benzene ring.
Dependencies are inferred from the claim text.