US 9,299,468 B2Granted

Radioisotope generator system including activity measurement and dose calibration

AssigneeBracco Diagnostics Inc.

InventorsStephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda

Life of this patent

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Abstract

Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer includes pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.

Claims29

Dependent claims

A mobile radioisotope generator system comprising:

a movable platform carrying an infusion tubing circuit, an activity detector, a dose calibrator, a computer, and a shielding assembly containing a strontium/rubidium radioisotope generator configured to generate a radioactive eluate via elution of an eluant,
the infusion tubing circuit including a tubing line connected between the strontium/rubidium radioisotope generator and the dose calibrator and configured to supply a portion of radioactive eluate to the dose calibrator,
the activity detector being positioned downstream of the strontium/rubidium radioisotope generator and configured to measure an activity of the radioactive eluate flowing through the infusion tubing circuit, and
the computer being electronically coupled to the dose calibrator and configured to execute automated quality control testing using the dose calibrator,
wherein the computer is configured to determine an activity of strontium-82 and an activity of strontium-85 in the portion of radioactive eluate through automated quality control testing using the dose calibrator,
the computer is configured to control the mobile radioisotope generator system to deliver a dose of radioactive eluate to a patient during a patient infusion procedure, and
the computer is further configured to prevent the patient infusion procedure if a quality control test result exceeds an allowable limit.

4 more elements

A mobile radioisotope generator system comprising:

a shielding assembly configured to contain a strontium/rubidium radioisotope generator that generates radioactive eluate via elution of an eluant and an infusion tubing circuit comprising an eluate tubing line configured to convey eluate from the strontium/rubidium radioisotope generator;
means for measuring an activity of the eluate flowing through the eluate tubing line;
means for receiving eluate from the eluate tubing line and measuring breakthrough activity of the eluate;
and
means for receiving activity data from the means for measuring the activity of the eluate and controlling the mobile radioisotope generator system based on the received activity data to deliver a dose of eluate to a patient during a patient infusion procedure,
wherein the means for receiving activity data and controlling the mobile radioisotope generator system is further configured to receive breakthrough activity data from the means for receiving eluate and measuring breakthrough activity, determine at least an activity of strontium-82 and an activity of strontium-85 in the eluate from the breakthrough activity data, and prevent the patient infusion procedure if the activity of strontinum-82 or the activity of strontium-85 exceeds an allowable limit.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 14/455,631Filed 8 Aug 2014 · continuation
Priority: 11 Jun 2008
Published: US 2014/0374615 A125 Dec 2014
Granted: 29 Mar 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification60 codes

A61M 5/007
Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning…:…
A61B 6/037
Computed tomography [CT]: emission tomography
A61B 6/107
Safety means specially adapted therefor: protection against radiation, e.g. shielding
A61B 6/481
Diagnostic techniques: involving the use of contrast agents

Family

Application12/137,356Parent of this continuation · filed 11 Jun 2008
Application12/137,363Parent of this continuation · filed 11 Jun 2008
Application12/137,364Parent of this continuation · filed 11 Jun 2008
Application12/137,377Parent of this continuation · filed 11 Jun 2008
PCT/US2009/047031Parent of this continuation · filed 11 Jun 2009
US 2014/0374615 A1Pre-grant publication · published 25 Dec 2014
Application12/808,467Parent of this continuation
US 8,317,674 B2Parent of this continuation
US 7,862,534 B2Parent of this continuation
US 8,708,352 B2Parent of this continuation
US 2009/0309465 A1Published application
US 2009/0309466 A1Published application
US 2009/0312630 A1Published application
US 2009/0318745 A1Published application
US 2011/0172524 A1Published application
US 8,273,008 B2Related patent
US 9,597,053 B2Related patent
US 9,607,722 B2Related patent
US 9,299,468 B2This patent

From the US filing history. Foreign family members aren’t listed.