Recombinant microorganisms and methods of use thereof
AssigneeLanzatech New Zealand Limited
InventorsMichael Koepke, Shilpa Nagaraju, Wendy Yiting Chen
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Abstract
The invention relates to methods for the production of chemical compounds, particularly but not exclusively ethanol, by microbial fermentation. Also described are genetically modified micro-organisms capable of using carbon monoxide to produce one or more products, particularly but not exclusively ethanol as a main product, and producing a reduced amount or substantially no 2,3-butanediol and/or a precursor thereof.
Claims17
A method of producing a product comprising culturing a recombinant carboxydotrophic acetogenic microorganism in the presence of a gaseous substrate to produce at least one product, wherein the microorganism comprises at least one genetic modification that disrupts the expression and/or activity of an enzyme in the 2,3-butanediol biosynthesis pathway selected from the group consisting of (i) an enzyme capable of converting pyruvate to acetolactate, (ii) an enzyme capable of converting acetolactate to acetoin, and (iii) an enzyme capable of converting acetoin to 2,3-butanediol.
Dependencies are inferred from the claim text.