Method for enucleating nucleated erythrocyte, and enucleation inducer

An enucleation inducer comprising a compound and a stabilizer, wherein the compound is selected from any one of the following peptides:

• (1) a peptide set forth in SEQ ID NO:
• 11;
• (2) a peptide set forth in SEQ ID NO:
• 13;
• (3) a peptide set forth in SEQ ID NO:
• 14;
• (4) a peptide set forth in SEQ ID NO:
• 15;
• (5) a peptide set forth in SEQ ID NO:
• 16;
• (6) a peptide set forth in SEQ ID NO:
• 18;
• (7) a peptide set forth in SEQ ID NO:
• 19;
• (8) a peptide having 98% or more homology to the peptide according to any one of the items (1) to (7) and having substantially the same enucleation induction action on a nucleated erythrocyte as the peptide;
• (9) a peptide having 1 to 2 amino acid substitutions, deletions, insertions, and/or additions in the peptide according to any one of the items (1) to (7) and having substantially the same enucleation induction action on a nucleated erythrocyte as the peptide,
• (10) a protected derivative, a glycosylated product, an acylated derivative, or an acetylated derivative of the peptide according to any one of the items (1) to (9);
• and
• (11) a peptide including the peptide according to any one of the items (1) to (9), and
• wherein the stabilizer is selected from human serum albumin, glucose, mannose, galactose, fructose, mannitol, inositol, xylitol, sucrose, maltose, lactose, dextran, hydroxypropyl starch, chondroitin sulfate, hyaluronic acid, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, and/or carboxymethylcellulose sodium.