Peptides that modulate complex SASPase-FLG2
AssigneeL'oreal
InventorsDominique Bernard, Agnes Thomas-Collignon
Life of this patent
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Abstract
An isolated peptide from skin aspartic protease (SASPase) or filaggrin-2 (FLG2), a fragment or homologue thereof, which can modify the three-dimensional shape of a complex formed by interaction between a first amino acid sequence from filaggrin-2 and a second amino acid sequence from SASPase, is described. The isolated peptide is useful as a target for screening for cosmetic or therapeutic active agents with regard to the skin and/or its appendages.
Claims3
A chimeric peptide comprising a first amino acid sequence from filaggrin-2 fused to a second amino acid sequence,
- wherein the first amino acid sequence represents a peptide represented by the amino acid sequence selected from the group consisting of SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, and SEQ ID NO:
- 15, and a homolog having a sequence identity of at least 85% to SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14 and SEQ ID NO:
- 15 and modifies the three-dimensional conformation of a complex formed by interaction of filaggrin-2 with skin aspartic protease.
An isolated complex formed by interaction of a first amino acid sequence from filaggrin-2 with a second amino acid sequence from skin aspartic protease, or a homolog thereof having a sequence identity of at least 85%,
- wherein the first amino acid sequence represents a peptide represented by the amino acid sequence selected from the group consisting of SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, and SEQ ID NO:
- 15, and a homolog having a sequence identity of at least 85% to SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14 and SEQ ID NO:
- 15 and modifies the three-dimensional conformation of a complex formed by interaction of the first amino acid sequence with the second amino acid sequence.
Dependencies are inferred from the claim text.