Compositions and methods for the treatment of viral infections
AssigneeDana-Farber Cancer Institute, Inc.
InventorsLoren D. Walensky, Gregory H. Bird
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Abstract
The invention provides compositions, kits and methods utilizing polypeptides having a viral alpha-helix heptad repeat domain in a stabilized α-helical structure (herein also referred to as SAH). The compositions are useful for treating and/or preventing viral infections. The invention is based, at least in part, on the result provided herein demonstrating that viral hydrocarbon stapled alpha helical peptides display excellent proteolytic, acid, and thermal stability, restore the native alpha-helical structure of the peptide, are highly effective in interfering with the viral fusogenic process, and possess superior pharmacokinetic properties compared to the corresponding unmodified peptides.
Claims11
A modified polypeptide for oral administration to a subject comprising a stabilized alpha helix of HIV gp41 heptad repeat domain, wherein said stabilized HIV gp41 heptad repeat domain is stabilized with two hydrocarbon staples, wherein said hydrocarbon staples are positioned so as to link amino acid residues i and i+4, and wherein said polypeptide is detectable intact in the blood of a subject 30 minutes after oral administration of said polypeptide to said subject.
Dependencies are inferred from the claim text.