Tolerogenic synthetic nanocarriers for allergy therapy

A composition comprising:

• (i) a first population of polymeric synthetic nanocarriers that are coupled to rapamycin, and
• (ii) a second population of polymeric synthetic nanocarriers that are coupled to antigens that comprise Major Histocompatibility Complex (MHC) Class II-restricted epitopes of an allergen, wherein the composition comprises substantially no B cell epitopes of the allergen, and
• wherein the load of the rapamycin on average across the first population of polymeric synthetic nanocarriers is at least 2% but no more than 25% (weight/weight), wherein the load of the antigens on average across the second population of polymeric synthetic nanocarriers is between 1% and 10% weight/weight,
• wherein the composition is in an amount effective to reduce the generation of an undesired immune response against the allergen,
• wherein at least 75% of the polymeric synthetic nanocarriers of the first population of synthetic nanocarriers have a minimum dimension, obtained using dynamic light scattering, that is greater than 110 nm and a maximum dimension, obtained using dynamic light scattering, that is equal to or less than 500 nm.