Use of HSP70 as a regulator of enzymatic activity
AssigneeOrphazyme ApS
InventorsThomas Kirkegaard Jensen, Marja H. Jaattela
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Abstract
The present invention concerns a method for modulating the enzymatic activity of an enzyme, wherein said enzyme interacts with BMP, said method comprising the step of administering or inducing Hsp70, or a functional fragment or variant thereof, in a form suitable for allowing interaction between BMP and Hsp70, or said functional fragment or variant thereof, and thereby modulating the enzymatic activity of an enzyme interacting with BMP.
Claims14
A method for treatment of a lysosomal storage disease comprising administering to an individual in need thereof a bioactive agent capable of increasing the intracellular concentration of Hsp70 by amplifying Hsp70 gene expression, wherein said bioactive agent is a hydroxylamine derivative.
Dependencies are inferred from the claim text.