Product and process for liquefaction of mucus or sputum
AssigneeNational Jewish Health
InventorCarl W. White
Life of this patent
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Abstract
Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin active-site in reduced state and optionally further contains a reducing system.
Claims16
A method of treating abnormal or excessively viscous or cohesive mucus or sputum in a patient, comprising contacting the mucus or sputum of the patient with a composition comprising a thioredoxin protein or peptide having a thioredoxin active site and having an amino acid sequence that is at least 80% identical to SEQ ID NO:12 and a pharmaceutically acceptable carrier, wherein the composition comprises about 0.25 mg to about 50 mg of the thioredoxin protein or peptide per dosing unit.
Dependencies are inferred from the claim text.