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US 9,289,449 B2Granted
Hydrogel compositions
AssigneeSpotLight Technology Partners LLC
InventorsScott Robert Sershen, Suresh Subraya Pai, Glen Gong
Life of this patent
Estimating the term…
Abstract
Fragmented polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.
Claims18
A hydrogel composition, comprising
- a polysaccharide or derivative thereof having a molecular weight of 1000 Dalton to 80,300 Dalton, a degree of deacetylation of 70% to 99%, and at least two nucleophilic groups, wherein the polysaccharide or derivative thereof is soluble in an aqueous solution;
- a multifunctional, multi-armed polyethylene glycol polymer of a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two nucleophilic groups;
- and
- a multifunctional, multi-armed crosslinker of polyethylene glycol having a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two electrophilic groups,
- wherein the hydrogel composition comprises:
- a covalent bond between the polysaccharide or derivative thereof and polyethylene glycol polymer;
- a covalent bond between the polysaccharide or derivative thereof and the multi-armed crosslinker;
- and
- a covalent bond between the polyethylene glycol polymer and the multi-armed crosslinker,
- wherein the polysaccharide or derivative thereof does not act as a cross-linking agent in the hydrogel.
7 more elements
A hydrogel composition, comprising
- a chitosan or derivative thereof having a molecular weight of less than or equal to 5,000 Dalton, a degree of deacetylation of 70% to 99%, and at least two nucleophilic groups, wherein the chitosan or derivative thereof is soluble in an aqueous solution;
- a multifunctional, multi-armed polyethylene glycol polymer of a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two nucleophilic groups;
- and
- a multifunctional, multi-armed crosslinker of polyethylene glycol having a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two electrophilic groups;
- wherein the polyethylene glycol polymer comprises ester groups to provide for degradation via hydrolysis and wherein the hydrogel composition comprises:
- a covalent bond between the chitosan or derivative thereof and polyethylene glycol polymer;
- a covalent bond between the chitosan or derivative thereof and the multi-armed crosslinker;
- and
- a covalent bond between the polyethylene glycol polymer and the multi-armed crosslinker,
- wherein the polysaccharide or derivative thereof does not act as a cross-linking agent in the hydrogel.
7 more elements
Dependencies are inferred from the claim text.