Diagnostic method for Alzheimer's disease
AssigneeRandox Laboratories Limited
InventorsEllen Umlauf, Maria Zellner
Life of this patent
Estimating the term…
Abstract
The present invention provides an ex vivo method for aiding the diagnosis of Alzheimer's disease in a patient, the method comprising the steps of determining the level of expression of at least four platelet proteins in a platelet sample from the patient selected from monoamine oxidase-B, coagulation factor Xllla, total tropomyosin (a and 13), WD-repeat protein 1 and apolipoprotein E4; and comparing the result of (i) to a control value, wherein a result higher than the control value is indicative of Alzheimer's disease. Preferably, the method of the invention further comprises determining the level of expression of wild-type GSTO-1 or mutant GSTO-1.
Claims13
An ex vivo method for detecting platelet proteins, comprising
- detecting at least four platelet proteins in a platelet sample from the patient selected from monoamine oxidase-B, coagulation factor XIIIa, total tropomyosin (α and β), WD-repeat protein 1 and apolipoprotein E4 (ApoE4), wherein said detecting comprises contacting a biochip array with the platelet sample, wherein the biochip array comprises a solid support having antibodies of the platelet proteins immobilized thereon.
A solid support comprising antibodies of at least four platelet proteins selected from monoamine oxidase-B, coagulation factor XIIIa, tropomyosin (α and β), WD-repeat protein 1 and ApoE4, immobilized thereon.
Dependencies are inferred from the claim text.