Silylated biomolecules
AssigneesInstitut National De La Sante Et De La Recherche Medicale (Inserm), Universite De Nantes, Chu Nantes, Institut Francais De Recherche Pour L'exploitation De La Mer (Ifremer)
InventorsPierre Weiss, Jerome Guicheux, Gildas Rethore, Emile Rederstorff, Samia Laib
Life of this patent
Estimating the term…
Abstract
The invention concerns: —a silylated biomolecule having the following formula (I): —the process for the preparation of a silylated biomolecule of formula (I), —the use of a silylated biomolecule of formula (I) to functionalize the surface of a support, —a process for the preparation of a hydrogel by use of a silylated biomolecule of formula (I), the hydrogel obtainable by said process, —said hydrogel as a biological tissue substitute, —a composition comprising said hydrogel in a pharmaceutically acceptable vehicle, —said composition for the release of active principle.
Claims20
A hydrogel prepared by a process comprising the steps of:
- a) contacting a silylated biomolecule with a base or an acid, in an aqueous medium, wherein the silylated biomolecule has the following formula (I):
- wherein:
- A is a biomolecule selected from the group consisting of a hyaluronic acid, pectin, collagen, gelatin, RGDS (SEQ ID NO:1) and chitosan,
- m is an integer ranging from 1 to 6,
- p and q are independently 0 or 1,
- X is a group chosen from —NHCONH—, —OCONH— and —CONH—, and
- R1, R2 and R3 each independently represent a C1-C6 alkyl group;
- and
- b) adjusting the pH of the aqueous medium of comprising the silylated biomolecule of step a) to a pH of between 3.5 and 12.4;
- whereby said silylated biomolecule auto-condensates via formation of —Si—O—Si—covalent bonds.
A biological tissue substitute comprising a hydrogel prepared by a process comprising the steps of:
- a) contacting a silylated biomolecule having the following formula (I):
- wherein:
- A is a biomolecule selected from the group consisting of a hyaluronic acid, pectin, collagen, gelatin, RGDS (SEQ ID NO:1) and chitosan,
- m is an integer ranging from 1 to 6,
- p and q are independently 0 or 1,
- X is a group chosen from —NHCONH—, —OCONH— and —CONH—, and
- R1, R2 and R3 each independently represent a C1-C6 alkyl group;
- with a base or an acid in an aqueous medium;
- and
- b) adjusting the pH of the aqueous medium of step a) to a pH of between 3.5 and 12.4.
A process for the preparation of an hydrogel comprising the steps of:
- a) contacting a silylated biomolecule with a base or an acid, in an aqueous medium, wherein the silyated biomolecule has the following formula (I):
- wherein:
- A is a biomolecule selected from the group consisting of hyaluronic acid, pectin, collagen, gelatin, RGDS (SEQ ID NO:1) and chitosan,
- m is an integer ranging from 1 to 6,
- p and q are independently 0 or 1,
- X is a group chosen from —NHCONH—, —OCONH— and —CONH—, and
- R1, R2 and R3 each independently represent a C1-C6 alkyl group;
- and
- b) adjusting the pH of the aqueous medium comprising the silylated biomolecule of step a) to a pH of between 3.5 and 12.4;
- whereby said silylated biomolecule auto-condensates via formation of —Si—O—Si—covalent bonds.
Dependencies are inferred from the claim text.