Application of highly conserved domain sequences from viral genome as template to design therapeutic sliRNAs
AssigneeBiocross Institute of Molecular Medicine (Nantong) Co., Ltd.
InventorsYork YuanYuan Zhu, Li Chen, Tiejun Li, Yixiang Lu, YunCheng Sun, Jinkang Wang
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Abstract
This invention relates to the application of the highly conserved sequences of viral genome, especially from a highly conserved domain of enteroviral genome as templates to design target small ligand RNAs (sliRNAs). The resulting sliRNAs are therapeutically active ingredients in the treatment of the related diseases caused by pathological angiogenesis.
Claims17
An sliRNA for modulating a Toll-like Receptor (TLR), comprising a nucleotide sequence that is 14-25 nucleotides in length and at least 90% identical to a fragment of a highly conserved domain of a viral genome sequence of a picornavirus, wherein the sliRNA has a GC content of at least 40% and comprises a double-stranded RNA, wherein the double-stranded RNA is either blunt ended or has a length of 14 to 25 nucleotides, and wherein said highly conserved domain sequence is located in nucleotides from 241 to 263 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.