Back to results
US 9,284,548 B2Granted
High affinity adaptor molecules for redirecting antibody specifity
AssigneeTripep AB
InventorsAlbert Collinson, Peter Wagner, Matti Sällberg, Anders Vahlne, Gregor Schürmann, Robert Kamen
Life of this patent
Estimating the term…
Abstract
Disclosed are methods for identifying high affinity adaptor molecules that bind to both a circulating antibody and a target molecule and redirect the specificity of the circulating antibody to the target molecule. Exemplary high affinity adaptor molecules are also provided.
Claims20
A method for identifying a high affinity adaptor molecule capable of redirecting the specificity of a circulating antibody, the method comprising:
- (a) providing a randomized library encoding a population of non-naturally occurring candidate targeting peptides, wherein each targeting peptide comprises one or more D-amino acids;
- (b) selecting a non-naturally occurring targeting peptide from the library which binds with high affinity and/or selectivity to a cytokine or growth factor target molecule;
- (c) linking the non-naturally occurring targeting peptide to a ligand moiety via a linking moiety to form a candidate adaptor molecule, wherein the ligand moiety comprises a glycan moiety or a peptidomimetic thereof;
- and
- (d) evaluating the ability of the candidate adaptor molecule to redirect the specificity of the circulating antibody to the cytokine or growth factor target molecule;
- thereby identifying the adaptor molecule.
3 more elements
Dependencies are inferred from the claim text.