Methods and reagents for preparing multifunctional probes
AssigneeThe General Hospital Corporation
InventorsLee Josephson, Elisabeth Garanger
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Abstract
Multifunctional probes include a substrate (e.g., a nanoparticle, polymer, antibody, protein, low molecular weight compound, drug) and a multifunctional single-attachment-point (MSAP) reagent. The MSAP reagents can include three components: (i) a peptide scaffold, (ii) a single chemically reactive group on the peptide scaffold for reaction of the MSAP with a substrate having a complementary reactive group, and (iii) multiple functional groups on the peptide scaffold. The peptide scaffold can include any number of residues; however, for ease of synthesis and reproducibility in clinical trials, it is preferred to limit the residues in the peptide to 20 or less.
Claims21
A reagent for preparing a multifunctional probe including a substrate, the reagent comprising:
- a peptide scaffold having a reactive group suitable for reacting with a complementary reactive group on the substrate;
- a first functional group attached to the scaffold;
- and
- a second functional group attached to the scaffold, the second functional group being different from the first functional group,
- wherein the peptide includes 20 or less amino acid residues, and
- wherein the first functional group and the second functional group are different from natural side chains of the amino acid residues of the peptide.
Dependencies are inferred from the claim text.