Anti-ErbB3 antibodies and uses thereof
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsChristopher Daly, Douglas MacDonald, Xunbao Duan
Life of this patent
Estimating the term…
Abstract
The present invention provides antibodies that bind to ErbB3 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human ErbB3. In certain embodiments, the antibodies of the present invention block the interaction of ErbB3 with an ErbB3 ligand such as neuregulin 1. The antibodies of the invention are useful for the treatment of various cancers.
Claims23
A method for inhibiting tumor growth, the method comprising administering to a subject afflicted with an ErbB3-expressing tumor a pharmaceutical composition comprising a monoclonal antibody or an antigen-binding fragment thereof that specifically binds human ErbB3, wherein the antibody or antigen-binding fragment thereof interacts with amino acids 345-367 of SEQ ID NO:498, amino acids 423-439 of SEQ ID NO:498, and amino acids 451-463 of SEQ ID NO:498, as determined by hydrogen/deuterium exchange.
A method for inhibiting tumor growth, the method comprising administering to a subject afflicted with an ErbB3-expressing tumor a pharmaceutical composition comprising an antibody or an antigen-binding fragment thereof that specifically binds ErbB3, wherein the antibody or antigen-binding fragment thereof comprises HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3 domains comprising the amino acid sequences, respectively, of SEQ ID NOs:
- 324, 326, 328, 332, 334 and 336.
Dependencies are inferred from the claim text.