Antibodies
AssigneeGenentech, Inc.
InventorsWei-Ching Liang, Gregory D. Plowman, Yan Wu, Weilan Ye
Life of this patent
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Abstract
The present invention relates to the use of VEGF antagonists and a novel anti-α5β1 antibody for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to compositions and kits comprising novel anti-α5β1 antibodies and methods of making and using them.
Claims9
An isolated nucleic acid molecule that encodes a humanized anti-α5β1 antibody comprising a light chain variable domain having the sequence set forth in any one of SEQ ID NOS:1, 2, 3, or 4 and a heavy chain variable domain having the sequence set forth in any one of SEQ ID NOS:5, 6, 7, 8, or 9.
Dependencies are inferred from the claim text.